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Instead, there is a component of the lizard's venom that is extremely helpful to certain
humans. A component in the Gila Monster's venom has proven remarkably effective in the control of Type II Diabetes in humans.
The Gila Monster is a protected species in the U.S. Fortunately, the exenatide drug can now be synthesized in the lab instead
of from live animals.
Diabetes is a chronic medical disorder generally characterized by high blood sugar (glucose)
levels, especially after eating. The diabetic patient must consistently monitor blood sugar levels to keep them within
a safe range.
When high blood sugar occurs, insulin is used to bring it down to a safer level. If low blood sugar
occurs, the patient generally consumes carbohydrates to raise the glucose level to a safe level. Type II Diabetes is a chronic
disorder characterized by resistance to insulin, a deficiency in insulin, and hyperglycemia (high blood sugar or excess glucose).
Exenatide helps with glucose (blood sugar) management in several ways:
1. It signals the pancreas to create
additional insulin when glucose levels are too high;
2. It regulates the liver so that it doesn't produce unneeded
glucose; and
3. It helps slow the rate at which sugar enters the bloodstream.
Studies showed that another
significant effect of exenatide use was weight loss. Overweight diabetes patients can have more difficulty controlling blood
sugar levels. The effectiveness of exenatide for diabetic blood glucose control stems from its ability to activate seve ral
glucose control pathways simultaneously.
Byetta (exenatide) is a wonderful drug, although its discovery sounds like
some kind of horror story. One can only imagine gruesome (but fictitious) clinical trials where unsuspecting diabetics are
asked to stick their arms into dark boxes containing Gila Monsters. This discovery sounds like one of those "good news/bad
news" jokes. For example, the doctor says, "The bad news is that the lizard probably won't release its bite on your leg for
another week. The good news is that your diabetes has improved!"
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